Determinants of transcription factor regulatory range
نویسندگان
چکیده
منابع مشابه
Transcription factor functionality and transcription regulatory networks.
Now that numerous high-quality complete genome sequences are available, many efforts are focusing on the "second genomic code", namely the code that determines how the precise temporal and spatial expression of each gene in the genome is achieved. In this regard, the elucidation of transcription regulatory networks that describe combined transcriptional circuits for an organism of interest has ...
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Sequence-specific binding by transcription factors (TFs) interprets regulatory information encoded in the genome. Using recently published universal protein binding microarray (PBM) data on the in vitro DNA binding preferences of these proteins for all possible 8-base-pair sequences, we examined the evolutionary conservation and enrichment within putative regulatory regions of the binding seque...
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Mammalian transcription factors (TFs) are often involved in differential cell-type- and context-specific transcriptional responses. Recent large-scale comparative studies of TF recruitment to the genome, and of chromatin structure and gene expression, have allowed a better understanding of the general rules that underlie the differential activities of a given TF. It has emerged that chromatin s...
متن کاملIdentifying the genetic determinants of transcription factor activity
Analysis of parallel genotyping and expression profiling data has shown that mRNA expression levels are highly heritable. Currently, only a tiny fraction of this genetic variance can be mechanistically accounted for. The influence of trans-acting polymorphisms on gene expression traits is often mediated by transcription factors (TFs). We present a method that exploits prior knowledge about the ...
متن کاملEvaluation of Transcription Factor Activity in Gene Regulatory Networks
Introduction Comprehending gene regulation has been a major endeavour in the field of bioinformatics for many years and still poses a difficult problem with a lot of uncertainties. In spite of improvements in the technologies used, e.g. high-throughput methods like ChIP-sequencing, and progress in the analysis of the driving regulators, large parts of many gene regulatory networks still remain ...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2020
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16106-x